Ageing is an
inevitable process. Each of us tries to postpone the time when all humorous
sayings about old age stop being amusing. Most women today have opted for career
growth and along with it constant stress, long days in stuffy offices, polluted
cities and bad habits. Given the faster pace of life and increased amounts of
physical and emotional stress nowadays, ageing is rapidly becoming one of
society’s greatest problems.
Skin ageing is a complicated process. The body changes with ageing and this affects one’s appearance, particularly skin. This process, however, affects the face as well as the body. The latest discoveries in genetics show that the ageing process is included in the genetic code of every human being. Each cell contains information on when and how it should age. However, the physiological condition of the cell is also an extremely important factor of the aging process. Inadequate supply of oxygen and nutrients, bad circulation and insufficient elimination of decay products leads to impaired functioning of cells which, in turn, disrupts the functioning of the entire organ – in this case, the skin – resulting in inevitable aging. International disease classification contains separate entries for nosologies related to age-related skin changes – namely, biological aging and photoageing.
Photoageing refers to skin changes caused by chronic exposure to radiation. UV-radiation is the main external aging factor. Excessive solar exposure leads to increased production of free radicals, which speed up oxidation processes, causing stress, cellular membrane and DNA damage in skin cells. Physiological tissue restoration processes are, in turn, slowed. The skin changes in tone, becomes flaccid and develops pigment spots.
Biological ageing includes:
1) chronoaging (natural aging, senile skin atrophy, dermolysis) is related to the ageing of the entire body. It is a biological process that is caused by genetically predetermined changes in the cells, such as metabolic disruptions, lower cytoplasmic enzyme activity and the prevalence of dissimilation processes over assimilation ones;
2) hormonal ageing – reproductive hormones target keratinocytes, fibroblasts, melanocytes, adipocytes and oil glands. Decreased reproductive hormone activity level and smaller amount of estrogens leads to skin dryness, small and deep wrinkles and creases, enlarged pores and dyschromia.
The pathogenetic ageing mechanism affects three main areas:
1) Inhibition of skin metabolic processes, such as cellular respiration, energy production, ion transport, synthesis of main structural proteins (collagen and elastin);
2) Impact of free radicals, which damage cellular membranes and DNA, causing cell death, destruction of collagen and disrupted microcirculation;
3) Disruption of the optimal water balance in the skin, leading to decreased amount of hyaluronic acid and its water-retaining capacity.
The variety of damage factors and pathogenetic mechanisms causing skin ageing makes it obvious that a pronounced anti-age effect is only possible with a comprehensive skin treatment. This treatment now exists in the form of the redermalization procedure – a system of complex interrelated biochemical, histological and morphological processes aimed at restoring the dermis in order to rejuvenate the skin. This procedure is the focus of our special issue.
The new generation formula Hyalual ® used for the redermalization procedure is a unique patented formula combining sodium succinate with hyaluronic acid, which affects all links of the pathogenetic aging mechanism. Sodium succinate has a powerful restorative and antioxidant effect, impedes the impact of free radicals and influences skin metabolism by enhancing cellular and tissue respiration, ion transport, protein synthesis and stimulating energy production. Hyaluronic acid eliminates skin dehydration and hydrates the skin by replenishing hyaluronic acid deficit in tissues.
Skin ageing is a complicated process. The body changes with ageing and this affects one’s appearance, particularly skin. This process, however, affects the face as well as the body. The latest discoveries in genetics show that the ageing process is included in the genetic code of every human being. Each cell contains information on when and how it should age. However, the physiological condition of the cell is also an extremely important factor of the aging process. Inadequate supply of oxygen and nutrients, bad circulation and insufficient elimination of decay products leads to impaired functioning of cells which, in turn, disrupts the functioning of the entire organ – in this case, the skin – resulting in inevitable aging. International disease classification contains separate entries for nosologies related to age-related skin changes – namely, biological aging and photoageing.
Photoageing refers to skin changes caused by chronic exposure to radiation. UV-radiation is the main external aging factor. Excessive solar exposure leads to increased production of free radicals, which speed up oxidation processes, causing stress, cellular membrane and DNA damage in skin cells. Physiological tissue restoration processes are, in turn, slowed. The skin changes in tone, becomes flaccid and develops pigment spots.
Biological ageing includes:
1) chronoaging (natural aging, senile skin atrophy, dermolysis) is related to the ageing of the entire body. It is a biological process that is caused by genetically predetermined changes in the cells, such as metabolic disruptions, lower cytoplasmic enzyme activity and the prevalence of dissimilation processes over assimilation ones;
2) hormonal ageing – reproductive hormones target keratinocytes, fibroblasts, melanocytes, adipocytes and oil glands. Decreased reproductive hormone activity level and smaller amount of estrogens leads to skin dryness, small and deep wrinkles and creases, enlarged pores and dyschromia.
The pathogenetic ageing mechanism affects three main areas:
1) Inhibition of skin metabolic processes, such as cellular respiration, energy production, ion transport, synthesis of main structural proteins (collagen and elastin);
2) Impact of free radicals, which damage cellular membranes and DNA, causing cell death, destruction of collagen and disrupted microcirculation;
3) Disruption of the optimal water balance in the skin, leading to decreased amount of hyaluronic acid and its water-retaining capacity.
The variety of damage factors and pathogenetic mechanisms causing skin ageing makes it obvious that a pronounced anti-age effect is only possible with a comprehensive skin treatment. This treatment now exists in the form of the redermalization procedure – a system of complex interrelated biochemical, histological and morphological processes aimed at restoring the dermis in order to rejuvenate the skin. This procedure is the focus of our special issue.
The new generation formula Hyalual ® used for the redermalization procedure is a unique patented formula combining sodium succinate with hyaluronic acid, which affects all links of the pathogenetic aging mechanism. Sodium succinate has a powerful restorative and antioxidant effect, impedes the impact of free radicals and influences skin metabolism by enhancing cellular and tissue respiration, ion transport, protein synthesis and stimulating energy production. Hyaluronic acid eliminates skin dehydration and hydrates the skin by replenishing hyaluronic acid deficit in tissues.